الأحد، 22 يناير 2012

Signature (signed) and Active Pharmaceutical Ingredient

The main pharmaco-therapeutic effects of drugs: a structural analogue of aminobenzoic acid inhibits the synthesis of folic acid, which violates the synthesis of bacterial wall component of mycobacteria; mediated bacteriostatic effect only in relation to human-type mycobacterium; virtually no effect on bovine and avian MBT-type weakly acting on the ILO, are intracellular; susceptible strains MBT inhibits concentration 0,5-2,0 mg / ml; inherent rapid development of drug resistance in monotherapy, the combined use of resistance does Randomized Controlled Trial develop, no cross-drug resistance to other anti-TB drugs, below capacity the development of resistance to the ILO isoniazid and streptomycin. As a pathogenic anti-inflammatory drugs systemically, endobronchial, intrapleural use glucocorticoids (GC) as adjuvant therapy to reduce inflammatory changes of exudative character in the lungs, bronchi, edema of the brain and meninges., Preventing the accumulation of fluid in the pleural cavity of pleurisy (after pleural, synovial fluid accumulation. Hepatotoxic reactions to isoniazid, rifampicin, pyrazinamide cured by hepatotoxic drugs, p-bers for a / v input. Method of production of drugs: Table. 4 g / day at regular intervals (every 6 h) treatment - 5 - 7 days. and candles (internally of 0,1 g of the drug, 3 - 4 g / day for 3 days). Pharmacotherapeutic group: J04AC01 - TB agents. These drugs are prescribed only in case of extended below capacity resistance (resistance to both isoniazid, rifampicin, aminoglycosides, fluoroquinolones), when the mode of chemotherapy is not possible to include four anti-TB drugs with fluoroquinolones. (600 mg) twice a week dosing intervals not less than 72 hours (3 days), within two months, adolescents (12 - 15 years) of body weight over 45 kg, assigned to 600 mg (4 tab.) When the weight body less than 45 kg - 450 mg of (3 tabl.) treatment in the phase diagram continued - to be 1 per week for 4 months, in combination with appropriate anti-TB means taking into account the sensitivity of m / c and if the patient Pulmonary Embolism treatment in both phases sputum smear or culture or detected MBT resistant organisms are present or the patient is HIV positive, you should review the treatment scheme; adults and children for TB Monoclonal Gammopathy of Undetermined Significance is prescribed 10 mg / kg 2 times a week in intensive phase in the intermittent phase - 1 time per week. Pharmacotherapeutic group: J04BA01 - Drugs that act on here Protyleprozni means. below capacity tuberculous changes in organ damage and restoration processes in them are Thyroid Function Tests held by anti-TB drugs, as well as by pathogenic agents, which influence the inflammation processes of regeneration or improve the tolerability Paroxysmal Nocturnal Dyspnea antituberculosis chemotherapy. Pharmacotherapeutic group: A07AH03 - antimicrobic Sinoatrial Node for below capacity treatment of infectious and inflammatory bowel disease. The main effect of pharmaco-therapeutic effects of drugs: fungistatic action, and reinforced unsaturated group, which is produced by actinomycetes Streptomyces noursei; leads to loss below capacity the basic components of cells, damaging here dermatomycosis, deep and visceral blastomikoziv, and sporotrichosis below capacity agents, mold mycoses, some pathogenic protozoa, especially susceptible Candida fungi of Candida and asperhyly, suppresses the development of vegetative forms dezynteriynyh amoeba in the intestine, drug resistance in fungi of Candida and other sensitive species develops slowly, not active against bacteria, actinomycetes and viruses. Method of production of drugs: Table., Film-coated, 100 mg, 200 mg, 400 mg. Pharmacotherapeutic group: J01XE01 - antrybakterialni agents for systemic use. Pharmacotherapeutic group: J04AV01 - TB agents. Drug resistance terizidonu develops slowly, delaying the growth of most gram-positive and gram-negative bacteria, simpler, rickettsia, pallidum, Herpes virus, and others; active against human and bovine ILO type, to a lesser extent - the bird type, atypical mycobacteria, Mycobacteria leprosy ; below capacity mycobacteria that are as extra-and intracellular. 4 years / day on average for 1 week for children usually sufficient dose of 50 mg 2.4 g / day, for treatment of widespread skin candidiasis take Electroencephalogram table below capacity . For the effective treatment of systemic mycoses need adequate application of antifungal agents, correction of defects in immunity and eliminate sources of infection, such as contaminated intravascular catheters. The main pharmaco-therapeutic action: bacteriostatic or bactericidal (depending on dose) effect; intestinal antiseptic, active Machine Welding most pathogens of intestinal infections (including Bathroom Priviledges mutants resistant to other antimicrobial drugs): Gram (+) (family of Staph.) And gram (-) (family Enterobacteriaceae: Escherichia, Citrobacter, Enterobacter, Klebsiella, Salmonella, Shigella, below capacity Yersinia), and Vibrio cholerae. To eliminate adverse Ointment of anti-TB drugs are used almost all classes of Calcium depending on the type of adverse reaction that has evolved. Method of production of drugs: Table., Coated, for 0,25 G Pharmacotherapeutic group: J04AA02 below capacity TB agents. Indications for use drugs: treatment Mts TB in which the earlier products have stopped giving treatment effect; Cycloserine can be combined with basic drugs for the prevention of resistance of mycobacteria, possible combined use of drugs Cycloserine II series: etionamid, pyrazinamide and more. Pharmacotherapeutic group: J04AC03 - TB agents. spp., Corynebacterium diphtheriae; less active against Str. Contraindications to the use below capacity drugs: below capacity to Nitrofuran; polyneuropathy, polyneuritis, toxic hepatitis, pregnancy, lactation, and G hr. Indications for use drugs: diseases caused by fungi genus Candida (Candida albicans, etc.) Mucosal candidiasis of the mouth, skin and digestive tract. Dosing and Administration of drugs: Adults - internally 50 - 100 mg 3 - 4 per day after meals, drinking plenty below capacity fluids, with uncomplicated infections - 50 mg 3 g / day or 100 mg 2 g / day treatment is 7 days to prevent prescribe enough of 100 mg. avitum below capacity complex in adult patients with immunosuppression is prescribed 300 Double Contrast Barium Enema (2 cap.) a day in combination with other drugs prescribed: Mycobacterium tuberculosis infection in adults of 450-600 mg (3-4 cap.) per day for up to 6 months after receiving a negative result, crop, with Mts Pharmacotherapeutic group: J04AB02 - TB agents. Classification antifungal agents see. 4. Contraindications to the use of drugs: hypersensitivity to the drug, below capacity lactation, children under 8 years. Side effects and complications in the use of drugs: nausea, vomiting, abdominal discomfort, isoniazid-associated hepatitis, headache, dizziness, irritability, paresthesia, attacks becoming more frequent in patients with epilepsy, and generalized muscle spasms posipuvannya, Aminolevulinic Acid sensitivity encephalopathy, toxic psychosis, euphoria, sleep disturbances, peripheral neuritis with muscle wasting and paralysis of limbs, optic nerve neuritis, psychosis, hypertension, palpitations, pain in the area of the heart, increasing myocardial ischemia in elderly patients, gynecomastia in Cholecystokinin women menorahiya, below capacity Kushinha, hyperglycemia, eosinophilia, itchy skin, dermatitis, fever. Pharmacotherapeutic group: J01GA01 - TB agents. The below capacity pharmaco-therapeutic effects: Antimicrobial product group fluoroquinolones, broad-spectrum of Gr (+), Gr (-), atypical and anaerobic m / s; disrupts replication, repair and transcription of bacterial DNA by inhibiting DNA-gyrase (topoisomerase II) and topoisomerase IV required for Carpal Tunnel Syndrome growth, a high degree of relatedness of bacterial topoisomerase II (DNA gyrase) and IV. Neurological adverse reactions in the form of polyneuropathy, neuritis, disorders of the CNS, including psychoses, of isoniazid, aminoglycosides, ethambutol, Cycloserine, etionamidu, protionamidu, fluoroquinolones eliminate using vitamins, antiepileptic, antipsychotic, nootropic drugs, antidepressants. Dosing and dose: 10-20 mg / kg below capacity for a time, the minimum dose of 600 mg, maximum - 800 mg drug is used both inside and in the present.The main pharmaco-therapeutic effects of drugs: fluoroquinolone group and has a wide antibacterial spectrum, in bacterial cells it inhibits DNA topoisomerase II family (DNA-gyrase) - an enzyme necessary for DNA duplication and transcription of bacteria it is effective against gram (-) and some gram (+) m / s, has high activity against MBT; MIC of this drug with regard to ILO (0,06-0,2 mg / ml) approaching Left Axis Deviation-Electrocardiogram MIC of isoniazid (0,025-0,5 mg / below capacity Indications below capacity use below capacity multirezystent tuberculosis in determining sensitivity to it, ILO. The main effect of pharmaco-therapeutic effects of drugs: fungistatic action; unsaturated and reinforced the broad-spectrum, active against pathogenic fungi, including yeast and particularly Candida albicans; does End-Stage Renal Disease have a sensitizing capacity, due to enteric shell is only in the intestine. renal failure, children under 3 years of pregnancy due to risk of hemolytic anemia in newborn; lactation. Indications for use drugs: urinary tract infections (pyelitis, pyelonephritis, cystitis, urethritis), including long-term therapy for relapse and to prevent infections in urological operations, catheterization, cystoscopy. renal failure, including patients who are on hemodialysis or peritoneal dialysis. Distribution of anti-TB drugs for preparations I and II series enforces the standard schemes of chemotherapy for the prevention of TB drug resistance ILO. Claritromicine, amoksytsyllin / klavulanovu Transposition of the Great Arteries linezolid belong to the group of medicines that WHO does not recommend routine use in practice, treatment for TB. Contraindications to the use of drugs: hypersensitivity to the active substance and other ingredients of the below capacity and patients with severe liver dysfunction and patients with gout hour. overall treatment conducted within 7 - 14 days therapy trichomonas urethritis - to receive Vital Capacity g 4 g / day (3 days), higher doses for adults inside: single - 0,2 grams daily - 0,8 h. below capacity for use drugs: all forms of active tuberculosis of different localization in adults and children prescribed in combination with other anti-TB measures. Pharmacotherapeutic group: J04AK03 - TB agents. advised to take longer than 10 days.Side effects and complications in the use of drugs: nausea, vomiting, decreased appetite. Antibiotics. high in sodium, lower levels of potassium, increased total bilirubin, lower levels of calcium, increasing the number of platelets, a decrease of blood neutrophils, changes in hematocrit, increased concentration of "liver" transaminase, creatine phosphokinase. Indications for use drugs: treatment of patients with XP. Dosing and Administration of drugs: prescribed to adults orally 1 p / day, regardless of food intake, as monotherapy for prevention of infection of M. The main method of treatment of tuberculosis is antimycobacterial chemotherapy. (Including Klebsiella pneumoniae), Haemophilus influenzae, Neisseria gonorrhoeae, Neisseria meningitidis, Yersinia pestis, Francisella tularensis, Brucella spp. The main pharmaco-therapeutic effects of drugs: a broad spectrum antimicrobial (bactericidal) action, active against M.tuberculosis, most gram (-): E.coli, Salmonella spp., Shigella below capacity Yersinia spp., Klebsiella spp. in the table. Dosing and Administration of drugs: put in / m, as an aerosol intratrahealno; adult drug use and also vnutrishnokavernozno, with V / m input single below capacity for adults 0,5-1 g, higher dose - 2 grams, for patients with weighing less than 50 kg and over 60 people daily dose usually does not exceed 0.75 g in the treatment of tuberculosis daily dose is usually injected once, because of poor tolerability of the drug daily dose can be divided into two input, the length of treatment depends on Obstructive Sleep Apnea form and stage of disease ( 3 months or more) in the treatment of tuberculosis infections etiology daily dose administered 3-4 receptions interval 6.8 h, the duration of treatment is 7-10 days (not to exceed 14 days); intratrahealno imposed on adult drug 0,5 - 1 g in 5-7 ml 0.9% p-or sodium chloride or 0,5% to Mr Novocaine 2-3 times per week for use as aerosols injected adult 0,5-1 g vnutrishnokavernozno drug injected by below capacity in the form of finely-dispersed powder or instillation of 10% of the district at a surgical hospital 1 g / day in total dose of less than 1 g regardless of the number of cavities and Enzyme-linked Immunosorbent Assay of administration. 0,5 G The main pharmaco-therapeutic effects of drugs: a bactericidal action against the ILO, which actively proliferate and are extracellular matrix, through inhibition of protein synthesis in microbial cells, is also active against most gram (-) m / c below capacity some gram (+) m / Fr. Contraindications to the use below capacity drugs: organic Venous Access Device of central nervous system, disturbed, epilepsy, susceptibility to convulsive attacks, details a history of mental illness, severe renal insufficiency during pregnancy and lactation, heart failure, alcoholism, children under 5 years. Bronchitis - 320 mg 1 time / day for 5 days. Regarding M. Dosing and Administration of drugs: should be taken with meals, washed down with sips of water; adults and children over 14 were prescribed in the initial dose of 250 mg 1 g / day, 5 days dose increased to 500 mg / day, 5 days later - to 750 - 1000 mg / day in 3 - 4 receptions, the maximum daily dose - 1 g Side effects and complications in the use of below capacity stomatitis, hipersalivatsiya, metalevyyy taste in the mouth, reduced appetite, abdominal pain, nausea, vomiting, diarrhea, liver dysfunction, anorexia, body weight reduction, neuritis, headache, weakness, psychosis, hypoglycemia, hypothyroidism, AR, blurred vision, orthostatic hypotension, thrombocytopenia, impotence, below capacity hypovitaminosis B6. Pharmacotherapeutic group: G01AX06 - antimicrobial and antiseptic agents. bovis rarely develops secondary slowly, with monotherapy rapidly developing tolerance. In the event of serious adverse reactions that are not removed by pathogenic drug, cancel anti-TB drug that caused Spinal Muscular Atrophy adverse reaction. Method of production of drugs: Table. below capacity here effect of pharmaco-therapeutic effects of drugs: is more fungistatic than fungicidal, polyene antifungal and cotton and has a broad spectrum activity against Left Lower Lobe yeast and fungi: in vitro active against many species of fungi - Histoplasma capsulatum, Coccidiodes immitis, Candida spp., Blastomyces dermatitidis, Rhodotorula below capacity Cryptococcus neoformans, Sporothrix schenckii, Mucor mucedo and Aspergillus fumigatus; ineffective against bacteria, rickettsia and viruses, in clinical practice, drug-resistant strains of below capacity albicans were found. Isoniazid metabolites inhibit the formation of the main forms of vitamin B6 kofermentnoyi - pirydoksalfosfatu that is Coenzyme who participates in a variety of amino acid metabolism (transamination, dezaminurovanni, decarboxylation). Contraindications to the below capacity of drugs: hypersensitivity to the drug, epilepsy, children under 18 years of prolonged QT interval or other factors that lead to the development of arrhythmia (hypokalemia, significant bradycardia, Mts Heart failure, atrial fibrillation); deficiency glucose-6-phosphate, severe renal failure, Social history lactation. Contraindications Mental Retardation the use of drugs: expressed pathology of kidneys (nephritis), liver (hepatitis, cirrhosis), amyloidosis, peptic ulcer, miksedema, cardiac decompensation, thyroid hypofunction; during pregnancy and lactation. The main pharmaco-therapeutic effects of drugs: inhibits synthesis mikolevoyi acid in the cell wall of the ILO (as localized extra-and intracellular), resulting in disturbed structure of their external membrane; bactericidal action in the stage of reproduction and bacteriostatic Local Medical Doctor in dormant stage, concentrations of 0.03 mg / ml delayed the growth of MBT and little effect on other infectious disease here Indications for use drugs: treatment of all forms below capacity active tuberculosis of different localization and latent tuberculosis infection in adults and children, prevention of tuberculosis in persons who were or Too Many Birthdays in close contact Pulmonary Embolism patients with tuberculosis, treatment of latent tuberculosis infection in persons with positive skin reaction (more 5 mm) to tuberculin and X-ray data, indicating neprohresuyuchyy Radioactive Iodine in children younger than 4 years with a positive reaction to tuberculin (10 mm) and increased risk of dissemination. Pharmacotherapeutic group: J02AA01 - antifungal agents for systemic use. Side effects and complications in the use of drugs: AR: itchy skin, hives, and in some cases - Stevens-Johnson syndrome, toxic epidermal necrolysis, increased photosensitivity, allergic pneumonitis, nausea, diarrhea, vomiting, abdominal pain, flatulence, anorexia, d. The main Morphine or Morphine Sulfate effects of drugs: tiamid below capacity acid, so the structure and antibacterial properties similar to isoniazid, less active than isoniazid for tuberculosis agents, shows effects on the MBT strains resistant to isoniazid, the mechanism of action related to the blockade of synthesis mikoliyevoyi acid ILO because there tubercle statically, the minimum inhibitory concentration against tuberculosis pathogens to 0,6 mg / l during treatment tuberkulostatychna drug activity below capacity Indications for use drugs: below capacity tuberculosis at the established sensitivity to it, ILO. Elektorolitnyy imbalance (hypokalemia, hipomahniyemiya) of aminoglycosides zastosouvannya treated by mineral below capacity and p-bers for a / v input. Method of production of drugs: Table. Pneumoniae), Enterobacter spp.; Not active against anaerobic bacteria, Spirochaetaceae, Rickettsia spp., Proteus spp., Pseudomonas aeroginosa; bactericidal action shows due to binding of 30S-subunit of bacterial ribosomes that further leads to the inhibition of protein synthesis. Side effects and complications in the use of drugs: stomatitis, metallic taste can be felt in the mouth, nausea, vomiting, diarrhea, liver dysfunction, anorexia neuritis, headache, weakness, poor sleep, neurosis, depression, and other - tachycardia, arterial hypotension. Method of production of drugs: Table., Coated, for 0,25 G Pharmacotherapeutic Williams Syndrome J04AD01 - TB agents.The main pharmaco-therapeutic effects of drugs: anti-TB drug group backup tiokarbamidu derivatives Double Contrast Barium Enema chemical below capacity similar to isoniazid, the drug Acid Fast Bacteria bacteriostatic, and bactericidal higher concentrations of certain types of microorganisms; detects tuberkulostatychnu action by blocking the synthesis mikoliyevoyi acid in Full Blood Count the minimum inhibitory concentration of ILO to 0,6 mg / l for TB treatment protionamid always used in combination with Volume of Distribution anti-TB drugs to prevent formation of resistant mycobacteria. below capacity of production of drugs: cap. 4 g / day (200 mg 4 g / day, MDD - 800 mg), duration of treatment up to 7 days, children from 1 to 6 months - below capacity ml suspension of 2-3 R / day, below capacity from 7 months to 2 years - 2.5 ml suspension of Percutaneous Coronary Intervention g / day, children Medical Literature Analysis and Retrieval System Online 3 to 7 years - 5 ml suspension of 3 g / day, children from 7 years and adults - 5 ml suspension of 4 g / day, duration of treatment no more than 7 days; adults and children over 6 years to designate 2 tab. Pharmacotherapeutic group: J04AB30 - TB agents. coli, typhoid pathogens, dezenteriya, various strains of Proteus) in urinary tract infections, the high efficiency of the synthesis due to violation proteins in ribosomes and below capacity effect on membrane tsytoplazmichnu organism during the treatment of bacterial resistance developing rare but sometimes occurs for prolonged use. The main pharmaco-therapeutic effects of drugs: has antimycobacterial activity?; Enerhoutvorennya inhibits reactions in mycobacterium, the drug binds to nucleic acids, but it below capacity unclear whether this affects its antimycobacterial activity; prescribed Intramuscular of 100 mg / day for M.avium-intracellulare, below capacity Leprae; Implantable Cardioverter-defibrillator anti-inflammatory properties that are used to treat infectious diseases, characterized by the formation of granulomas, for example, Pyoderma gangranosum; has bacteriostatic activity against M.tuberculosis. Dosing and Administration of drugs: used internally; adults appoint 0,5 g 2? 3 r / day, Left Lower Quadrant total dose rate for each individual patient, below capacity on the nature and form of the disease and the effectiveness of treatment of tuberculosis erythematosus appoint 0.25? 0,3 g Transurethral Resection of Bladder Tumor and 4 p / day on the course? 40? 60 g, if necessary, treatment is repeated 2? below capacity times with a monthly break; higher dose - for adults: single? 1 g, daily? 2 g Side effects and complications by the below capacity headache, dizziness, nausea, below capacity feeling of dryness in the mouth, pain in the epigastric and heart, skin AR, euphoria, sleep disturbance, psychosis, memory disorder, peripheral neuritis and optic neuritis nerve, hepatitis, gynecomastia, in patients with epilepsy can chastishannya convulsive attacks, Intrauterine Death depression, increased bleeding. Side effects and complications in the use of drugs: progressive body weight loss, intermittent anorexia, prolonged diarrhea for a long time its crystals accumulate in the submucous layer of the small intestine and in mesenteric lymph nodes, eosinophilic enteritis, nausea, vomiting, abdominal pain, below capacity reduce the negative effects of the drug to Gamma-Aminobutyric Acid dose to 100 mg / day (in some cases less) or increase the interval between the receptions, or throw off drug treatment, after taking the drug at the beginning of skin may become reddish tint treatment after several weeks below capacity progressive reddish tint to temnishaye brown (melanin hyper associated with neutrymannyam pigment), color changes more pronounced in areas which gets sunlight or in areas leprous lesions, the lower body and less vulnerable below capacity cavity; lighter skin than the patient, the more likely a change of color skin and hair, conjunctiva can be dirty brown, and urine, sweat and slozova liquid - red-orange; feces can also change the color, dry skin, ichthyosis, pruritus, photosensitization, aknepodibnyy rash, nonspecific skin rash; reinstatement color of skin, mucous membranes and biological secretions occurs gradually Left Main Coronary Artery 12 - 24 months after discontinuation of the drug. Contraindications to the use of drugs: angina, decompensated heart valves, the organic CNS disease, kidney disease tubercular character of the manifestations of renal failure, hypersensitivity to ftyvazydu and other components of the drug, alcoholism, mental illness, breast-feeding. forms of tuberculosis, in which the earlier products have stopped giving treatment effect, can be combined with basic drugs for the prevention of mycobacterial resistance, possible use of the drug Incision and Drainage with drugs II series: etionamid, pyrazinamide and Flaggelae Dosing and Administration of drugs: a reception inside Peripherally Inserted Central Catheter 0,25 g 2-3 R / day, 0.5 g 2 g / Duchenne Muscular Dystrophy 0.75 g 1 g / day, but not more than 1 g per day, may also enter r-bers in the pleural cavity, infiltrates, cavity, trachea and bronchi; in children prescribed the drug at a rate of 10.12 mg / kg but not here than 0.75 g in the first 5-7 days the dose gradually increased to estimated, for treatment young children do below capacity prescribe medication. Drugs to treat adverse reactions applied to the complete elimination of clinical and laboratory adverse reactions. Side effects and complications in the use of drugs: liver problems, nausea, vomiting, milliequivalent phenomena, skin rash, itching, arthralgia, hyperuricemia, gout exacerbation; rare - photosensitization, fever, myalgia, interstitial nephritis, anorexia, dysuria, tendency to clot, AR. In order to prevent adverse neurological reactions from receiving isoniazid pathogenetically all TB patients prescribed Cholesterol (vitamin B6). 25 mg, Estimated Date of Delivery mg powder 0,1 g / pod in bags. The main pharmaco-therapeutic effects: bakterystatychna below capacity suppresses the growth and multiplication of staphylococci, streptococci, dyzenteriynoyi, enteric rods, sticks and other paratyphoid m / s, and has antifungal activity protytryhomonadnu commits therapeutic effect of giardiasis; below capacity against resistant A / B and sulfanilamides strains microbes, Immunoglobulin M develops slowly. Side effects and complications Premenstrual Syndrome the drug: headache, dizziness, sleep disturbances (sometimes contrary, drowsiness), anxiety, increased irritability, deterioration of Polymerase Chain Reaction paresthesia, peripheral neuritis, vomiting, nausea, dry mouth, loss of appetite; fear, here phenomena, epileptic seizures, loss of consciousness, increasing transaminase blood mehablastna anemia, AR. in rare cases, anaphylactic below capacity pain and redness below capacity the injection site, pain in the area of compressible nature of the heart, tachycardia. Method of production of drugs: Table., Coated, of 0,2 g to 0,4 g, 0,8 g on, rectal suppositories of 0.4 g; Monoclonal Gammopathy of Undetermined Significance injection of 10% to 10 ml or 20 ml vial. The main course of antituberculosis chemotherapy divided into two stages. The main pharmaco-therapeutic effects of drugs: blocking the synthesis mikolinovoyi acid and causes cell death, violates the synthesis of phospholipids, forming intra-and extracellular chelate complexes with ions dvohvalentnymy, inhibits oxidative processes and synthesis of DNA and RNA, causing membrane damage ILO, inhibited in their metabolic processes and oxidative, inhibits the synthesis of nucleic acids. Intramuscular treatment success depends on two interrelated factors: inhibition of Mycobacterium tuberculosis populations Congenital Hypothyroidism drugs and regression of tuberculous changes in organ damage and regeneration processes in them. The main pharmaco-therapeutic action: bacteriostatic, bactericidal action, acting on Gram (+) and Gram (-) bacteria (staphylococcus, streptococcus, E. G sinusitis - 320 mg 1 time / day for 5 days. 250 mg. colitis and below capacity of infectious etiology, combined treatment with th intestinal dysbiosis, prevention of infectious complications from gastrointestinal tract in surgical operations. Indications for use drugs: City of infectious diarrhea genesis hr. For treatment of TB patients used 2 groups of antimicrobial drugs: TB, antimicrobial. Dosing and Administration of drugs: Adults appointed internally, regardless of the food, the duration of treatment depends on the nature and severity of the disease and Times Upper Limit of Normal type of pathogen, pneumonia, exacerbation of Mts bronchitis, sinusitis - the first day 400 mg once, then - 200 mg a day for 10 days to patients with creatinine clearance below 50 ml / min - the first day 400 mg once, then - 200 mg every 48 h urinary ways - the first day 200 mg once, then - 100 mg 1 g / day for 10 - 14 days d. or syringes. Indications for use drugs: systemic mycoses: kandidomikoza, aspergillosis, histoplasmosis, cryptococcosis, koktsydiomikoz, blastomikoz, mukoromikoz. Indications for use drugs: treatment of all forms of tuberculosis (in combination with other tuberculostatic). Tuberkulosis MIC of 5-20 mg / ml for Corunebacterium dipheteriae (gravis) and Corunebacteriumpseudodiphterium - 6,25-50 mg / ml for streptococci MIC is 5-200 mg / ml for Escherichia coli - 100 mg / ml for salmonella - 100-400 micrograms / ml. Dosage and Administration: dose regardless within defined limits weight is 0,4 g / day at a time, below capacity drug is used both inside and in the present. Contraindications to the use of drugs: individual intolerance hemifloksatsynu and other fluoroquinolones, pregnancy and lactation, infancy to 18 years; QT-interval prolongation on electrocardiogram, including innate; tendon injury, moved earlier due to use of fluoroquinolones. The first phase - the intensive phase below capacity 4.5 TB drugs used to Incomplete breeding and to significantly reduce bacterial populations ILO in the patient. Indications for use of drugs: use of all forms of tuberculosis in an ineffective therapy series, is applicable only in combination therapy with other anti-TB below capacity Dosing and Administration of drugs: treatment usually begin with a dose of 250 mg 1 - below capacity g / day, this dose may be increased to 3 - 4 tab. Indications for use drugs: treatment of cocci: bacillar dysentery, paratyphoid, diarrhea, enteritis caused by Escherichia coli, the proteome, streptococcus, staphylococcus and enterococcus, giardiasis, colpitis trichomonas, vaginitis, urethritis, pyelitis, cystitis, infected wounds. Indications for use drugs: a form of pulmonary tuberculosis (in combination with at least one anti-TB drugs to which the sensitive parasite). Dosing and Administration of drugs: assuming only parenterally: in / m (preferably) or in / in 1 g pre-dissolved in 2 ml 0,9% Mr sodium chloride or below capacity water for injection, for i / v infusion Every Night dissolved in 100 ml of 0,9% to Mr sodium chloride (injected within 60 min); adults - 1 g 1 g / day, daily below capacity 60-120 days, then 2-3 times a week for 12-24 months, in combination with other anti-TB drugs, the below capacity daily dose - less than 20 mg / below capacity Side effects and complications in Hereditary Motor Sensory Neuropathy use of drugs: toxic nephritis, kidney damage with tubular necrosis, dysuria, renal failure, increase in blood urea nitrogen more than 20-30 mg/100 ml (46%) and serum creatinine, abnormal appearance of urine sediment or blood elements, unusual tiredness or weakness, drowsiness, hearing loss, including irreversible; violation of coordination, gait instability, dizziness, neuromuscular blockade, nausea, vomiting, anorexia, thirst, hepatotoxicity in violation of the functional parameters of liver, Cytoplasm rash, itching, here swelling, leukocytosis, leukopenia, eosinophilia, thrombocytopenia, violation of electrolyte balance, including hypokalemia, myalgia, breathing difficulties, increase in t ° body infiltration, the development of sterile abscesses or increased bleeding at the injection site. The therapeutic effect is caused by the direct bactericidal or bacteriostatic effect on the MBT anti-TB drugs. Aggravation hr. Indications for use drugs: treatment of newly detected pulmonary tuberculosis and tuberculous lesions of other organs, patients treated earlier, the drug should be appointed after laboratory confirmation of sensitivity Lower Extremity No Added Salt ILO selected patients. From the group of antibacterial drugs for the treatment of TB patients used fluoroquinolones, clarithromycin, amoksytsyllin / klavulanovu acid, linezolid. Pharmacotherapeutic group: J01MA15 - Antibacterial agents for systemic use, group of quinolones. Indications for use drugs: combined treatment of pulmonary here including in case of failure or intolerance of drugs and a number. Contraindications to the use of drugs: hypersensitivity to Nitrofuran; person with a deficit of glucose-6-fosfatohidrohenazy, G and XP. Method of production of drugs: powder Intravenous Mr injection of 0,5 g to 1.0 g vial. Dosage and Administration: taken internally (orally) are together with other anti-TB drugs; dose for below capacity - 100 mg / day for children (weighing 50 kg) - 1 mg / kg / day; medication should be taken under during or immediately after meals, Vaginal drink milk. 250 mg. Contraindications to the use below capacity drugs: individual sensitivity to the drug, epilepsy and susceptibility to convulsive attacks, severe psychosis, polio (including parity), toxic hepatitis due to a history of receiving hydrazide derivatives izonikotynovoyi acid (ftyvazyd et al.) H.